Keywords
microRNAs
microbiota
intestinal permeability
autoantibodies
How to Cite
Abstract
Problem: The increase in infertility worldwide is not only linked to the increase in maternal age but also to the impact of environmental factors associated to epigenetic changes in women’s health status, which have an impact on the origin of inflammatory disorders whose first symptom could be infertility. Method of study: A total of 301 women with multiple IVF-ET failures were recruited. The expression of specific microRNAs associated with microbiota imbalances was analyzed together with biomarkers in blood and saliva. All patients showed imbalances in at least one of the above-mentioned biomarkers and decided to continue with their usual treatment (n=23) or to customize dietary and probiotic supplementation for 75 days (n=278). Pregnancy rate was compared between both groups after 180 days of pregnancy search. Result(s): 84% of the infertile patients showed an increase in at least one of these microRNAs. Considering these parameters and peripheral blood and saliva biomarkers, the patients were supplemented with a combination of biomedical diets, probiotics and nutraceuticals. Pregnancy rate after another IVF-ET attempt was 75% for the group that customized supplementation and 30% for the group that did not supplement according tests results (*p<0.05). Conclusions: Appropriate dietary supplementation according to our novel microRNA diagnostic platform improved the pregnancy rate of patients with multiple IVF-ET failures.
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