Keywords
ndocannabinoids
endocrine system
diabetes
reproduction
How to Cite
Abstract
The medicinal properties of the cannabis plant are known worldwide as well as the effects of its synthetic derivatives in the therapeutics of different diseases. In countries where medicinal consumption has been legalized, its usefulness in the treatment of diseases of the central nervous system has generated extensive benefits in patients. In recent decades, its palliative effect of chronic pain in patients with oncological or degenerative pathologies and its antiproliferative and immunomodulating benefits have become relevant. The endocannabinoid system is represented by endogenous ligands, derived from fatty acids, which have effects on receptors expressed in different locations of the body. Over the years, multiple target sites have been described, including the organs of the endocrine system. Despite these advances, it remains a challenge to determine with certainty the effects, the therapeutic dose for each individual and the detection of synthetic ligands agonists and selective antagonists for the different receptors. In this review we will describe the general aspects of the endocannabinoid system and its effects on endocrine organs, focusing on the implications for carbohydrate metabolism, adipose tissue and reproductive function.
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