Palabras clave
endocannabinoides
sistema endocrino
diabetes
reproducción
Cómo citar
Resumen
Son conocidas las propiedades medicinales de la planta de cannabis a nivel mundial así como los efectos de sus derivados sintéticos en la terapéutica de diferentes enfermedades. En los países donde el consumo medicinal ha sido legalizado su utilidad en el tratamiento de enfermedades del sistema nervioso central ha generado amplios beneficios en los pacientes. En las últimas décadas ha tomado relevancia su efecto paliativo del dolor crónico en pacientes con patologías oncológicas o degenerativas y sus beneficios antiproliferativos e inmunomduladores. El sistema endocannabinoide está representado por ligandos endógenos, derivados de ácidos grasos, que tienen efectos sobre receptores expresados en distintas localizaciones del organismo. En el transcurso de los años se han descripto múltiples sitios target entre ellos los órganos del sistema endócrino. A pesar de estos avances sigue siendo un desafío determinar con certeza los efectos, la titulación de la dosis terapéutica para cada individuo y la detección de ligandos sintéticos agonistas y antagonistas selectivos para los diferentes receptores. En esta revisión describiremos los aspectos generales del sistema endocannabinoide y sus efectos sobre los órganos endócrinos haciendo foco en las implicancias sobre el metabolismo de los hidratos de carbono, el tejido adiposo y la función reproductiva.
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